Ulcerative colitis (UC) is an inflammatory bowel disease that causes a variety of gastrointestinal symptoms, including increased stool frequency, rectal bleeding, and abdominal discomfort. It affects 1.3 million patients in the US and Europe and typically presents during the childhood or the young adult years. Ulcerative colitis is a chronic condition, characterized by cycles of exacerbation and remission, and is a risk factor for colon cancer. In the past, up to 30% of patients required surgery to remove the colon in patients due to severe or fulminant disease that was unresponsive to therapy. A new generation of biological drugs have shown promise in recent years for treating the most severe cases. Additional new therapies are badly needed for frontline treatment of mild-to-moderate disease, and to prevent the progression of the disease to more severe stages. Improving front-line therapy for UC is our goal for Zoenasa.
Important Ulcerative Colitis links: